Ontology highlight
ABSTRACT:
SUBMITTER: Godzik A
PROVIDER: S-EPMC48715 | biostudies-other | 1992 Apr
REPOSITORIES: biostudies-other
Godzik A A Skolnick J J Kolinski A A
Proceedings of the National Academy of Sciences of the United States of America 19920401 7
Simulations of the folding pathways of two large alpha/beta proteins, the alpha subunit of tryptophan synthase and triose phosphate isomerase, are reported using the knight's walk lattice model of globular proteins and Monte Carlo dynamics. Starting from randomly generated unfolded states and with no assumptions regarding the nature of the folding intermediates, for the tryptophan synthase subunit these simulations predict, in agreement with experiment, the existence and location of a stable equ ...[more]