Interleukin-37 expression and its potential role in oral leukoplakia and oral squamous cell carcinoma.

ABSTRACT: Interleukin 37 (IL-37) has been reported to play a significant role in innate immune response and to be involved in several kinds of cancers. However, the investigation of association between IL-37 and oral mucosa carcinogenesis hasn't been clearly established. The aim of the study was to assess IL-37 expression and explore its role in oral mucosa carcinogenesis. The expression of IL-37 increased from normal control (NC) to Oral leukoplakia (OLK) and oral squamous cell carcinoma (OSCC). Moreover, statistically highly significant difference was present between scores of OLK with and without mild/moderate dysplasia (P?

SUBMITTER: Lin L 

PROVIDER: S-EPMC4880905 | biostudies-other | 2016

REPOSITORIES: biostudies-other