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The PVT1-MYC duet in cancer.

ABSTRACT: Gain of 8q24, harboring the avian myelocytomatosis viral oncogene homolog (MYC), is a frequent mutation in cancers. Although MYC is the usual suspect in these cancers, the role of other co-gained loci remains mostly unknown. We have recently found that MYC partners with the adjacent long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1), which stabilizes MYC protein and potentiates its activity.

SUBMITTER: Tseng YY

PROVIDER: S-EPMC4904896 | biostudies-other | 2015 Apr-Jun

REPOSITORIES: biostudies-other

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