Mutant p53 exerts oncogenic functions by modulating cancer cell metabolism.
Ontology highlight
ABSTRACT: The metabolic function of p53 is important for its oncosuppressive function. Mutant p53 (mutp53) with gain of oncogenic function can regulate cell metabolism. Our recent study revealed a novel transcription-independent mechanism for a gain-of-function mutp53 that directly inhibits activation of adenosine monophosphate-activated protein kinase (AMPK) to promote cancer cell metabolism.
SUBMITTER: Zhou G
PROVIDER: S-EPMC4904903 | biostudies-other | 2014 Jul-Sep
REPOSITORIES: biostudies-other
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