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Microtubule plus tips: A dynamic route to chromosomal instability.


ABSTRACT: Although chromosomal instability (CIN) is a recognized hallmark of cancer the underlying mechanisms and consequences are largely unknown. However, it is accepted that lagging chromosomes represent a major prerequisite for chromosome missegregation in cancer cells. Here, we discuss how lagging chromosomes are generated and our recent findings establishing increased microtubule assembly rates as a source of CIN.

SUBMITTER: Stolz A 

PROVIDER: S-EPMC4905025 | biostudies-other | 2015 Apr-Jun

REPOSITORIES: biostudies-other

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