Pumilio and nanos RNA-binding proteins counterbalance the transcriptional consequences of RB1 inactivation.
Ontology highlight
ABSTRACT: The ability of the retinoblastoma protein (RB) tumor suppressor to repress transcription stimulated by the E2 promoter binding factors (E2F) is integral to its biological functions. Our recent report described a conserved feedback mechanism mediated by the RNA-binding proteins Pumilio and Nanos that increases in importance following RB loss and helps cells to tolerate deregulated E2F.
SUBMITTER: Miles WO
PROVIDER: S-EPMC4905203 | biostudies-other | 2014 Oct-Dec
REPOSITORIES: biostudies-other
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