Pro-survival role of p62 during granulocytic differentiation of acute myeloid leukemia cells.

ABSTRACT: p62 regulates key signaling pathways including those that control cell death and autophagy. Recently, we reported that p62 is upregulated during all-trans retinoic acid (ATRA)-induced terminal differentiation of acute myeloid leukemia (AML) cells. This response reduces levels of ubiquitinated protein aggregates in mature cells and protects these cells against ATRA treatment. Thus, p62 confers a survival advantage to mature AML cells.

SUBMITTER: Segal-Bendirdjian E 

PROVIDER: S-EPMC4905221 | biostudies-other | 2014 Oct-Dec

REPOSITORIES: biostudies-other