Unknown

Dataset Information

0

Nfkb1 suppresses DNA alkylation-induced tumor formation.


ABSTRACT: NF-κB proteins play a complex role in modulating carcinogenesis following DNA damage. Previous work identified p50/NF-κB1 as a necessary factor in the cytotoxic response to alkylation damage. Recently, these findings were extended to demonstrate that in the setting of alkylation damage, this NF-κB subunit acts as a haploinsufficient tumor suppressor that prevents hematologic malignancy formation.

SUBMITTER: Schmitt AM 

PROVIDER: S-EPMC4905238 | biostudies-other | 2015 Jan-Mar

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC11602140 | biostudies-literature
| S-EPMC3617098 | biostudies-literature
| S-SCDT-EMBOJ-2020-105806 | biostudies-other
| S-EPMC8126949 | biostudies-literature
| S-EPMC9381602 | biostudies-literature
| S-EPMC5100879 | biostudies-literature
| S-EPMC8892324 | biostudies-literature
| S-EPMC4541293 | biostudies-literature
| S-EPMC2937908 | biostudies-literature
| S-EPMC6828967 | biostudies-literature