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MiR-17-92 explains MYC oncogene addiction.

ABSTRACT: MYC regulates tumorigenesis by coordinating the expression of thousands of genes. We found that MYC appears to regulate the decisions between cell survival versus death and self-renewal versus senescence through the microRNA miR-17-92 cluster. Addiction to the MYC oncogene may therefore in fact be an addiction to miR-17-92.

SUBMITTER: Li Y

PROVIDER: S-EPMC4905255 | biostudies-other | 2014 Oct-Dec

REPOSITORIES: biostudies-other

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