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Fbw7 and Usp28 - enemies and allies.


ABSTRACT: The Usp28 deubiquitinase antagonizes Fbw7-mediated turnover of multiple oncoproteins, including Myc, Jun, and Notch, and promotes tumorigenesis in the intestine. Our recent study reveals that Usp28 also counteracts autocatalytic ubiquitination of Fbw7, suggesting a complex role for Usp28 in the regulation of Fbw7 activity and tumor development.

SUBMITTER: Taranets L 

PROVIDER: S-EPMC4905318 | biostudies-other | 2015 Jul-Sep

REPOSITORIES: biostudies-other

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