The PREX1/Rac signaling axis: Potential as a biomarker and therapeutic target in breast cancer.

ABSTRACT: PREX1 is a Rac guanine exchange factor that coordinates signaling inputs from G protein-coupled receptors and receptor tyrosine kinases (RTKs). PREX1 creates a positive feedback loop to drive RTK, phosphatidylinositol 3-kinase (PI3K)/AKT, and MEK/ERK signaling. High PREX1 levels predict sensitivity to PI3K inhibitors in breast cancer cells.

SUBMITTER: Dillon LM 

PROVIDER: S-EPMC4905322 | biostudies-other | 2015 Jul-Sep

REPOSITORIES: biostudies-other