Genomic instability establishes dependencies on acquired gene regulatory networks: A novel role of p62 in myeloid malignancies with del(5q).
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ABSTRACT: MiR-146a deletion is a driving molecular event in del(5q) myeloid malignancies, which acquire dependency on a nuclear factor kappa B (NF-κB) regulatory network. p62, a neighboring haploid 5q gene, is induced by NF-κB and required to sustain TRAF6-mediated NF-κB activation. Interfering with p62/TRAF6 binding may have a therapeutic benefit in miR-146a-deficient leukemic cells.
SUBMITTER: Fang J
PROVIDER: S-EPMC4905351 | biostudies-other | 2015 Oct-Dec
REPOSITORIES: biostudies-other
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