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ATG2B and GSKIP: 2 new genes predisposing to myeloid malignancies.

ABSTRACT: We have recently identified a 700-kb tandem duplication at locus 14q32.13-q32.2 involving 2 genes, autophagy-related protein 2 homolog B (ATG2B) and GSK3B interacting protein (GSKIP), that increases the predisposition to myeloid malignancies. Here, we discuss the clinical relevance of these findings.

SUBMITTER: Plo I 

PROVIDER: S-EPMC4905402 | biostudies-other | 2016 Mar

REPOSITORIES: biostudies-other

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ATG2B and GSKIP: 2 new genes predisposing to myeloid malignancies.

Plo Isabelle I   Bellanné-Chantelot Christine C   Vainchenker William W  

Molecular & cellular oncology 20151029 2

We have recently identified a 700-kb tandem duplication at locus 14q32.13-q32.2 involving 2 genes, autophagy-related protein 2 homolog B (ATG2B) and GSK3B interacting protein (GSKIP), that increases the predisposition to myeloid malignancies. Here, we discuss the clinical relevance of these findings. ...[more]