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Keeping autophagy in cheCK1.


ABSTRACT: Mutant RAS-driven cancer cells cope with proliferative stress by increasing basal autophagy to maintain protein/organelle and energy homeostasis. We recently demonstrated that casein kinase 1 alpha (CK1α), a therapeutically tractable enzyme, is critical for fine-tuning the transcriptional regulation of mutant RAS-induced autophagy and the development of mutant RAS-driven cancers.

SUBMITTER: Cheong JK 

PROVIDER: S-EPMC4909404 | biostudies-other | 2016 May

REPOSITORIES: biostudies-other

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