BMP2, a key to uncover luminal breast cancer origin linked to pollutant effects on epithelial stem cells niche.

ABSTRACT: Chronic exposure of epithelial cells to high levels of bone morphogenetic protein 2 (BMP2) has recently been demonstrated to initiate stem cell transformation toward a luminal tumor-like phenotype through a BMP2-BMPR1B-dependent mechanism. Carcinogen-driven deregulation of the stem cell niche could therefore represent a driving force to promote transformation and dictate the ultimate breast tumor subtype.

SUBMITTER: Chapellier M 

PROVIDER: S-EPMC4909443 | biostudies-other | 2016 May

REPOSITORIES: biostudies-other