Ontology highlight
ABSTRACT:
SUBMITTER: Achuthan A
PROVIDER: S-EPMC5004969 | biostudies-other | 2016 Sep
REPOSITORIES: biostudies-other
The Journal of clinical investigation 20160815 9
Data from preclinical and clinical studies have demonstrated that granulocyte macrophage colony-stimulating factor (GM-CSF) can function as a key proinflammatory cytokine. However, therapies that directly target GM-CSF function could lead to undesirable side effects, creating a need to delineate downstream pathways and mediators. In this work, we provide evidence that GM-CSF drives CCL17 production by acting through an IFN regulatory factor 4-dependent (IRF4-dependent) pathway in human monocytes ...[more]