Ontology highlight
ABSTRACT:
SUBMITTER: Reen FJ
PROVIDER: S-EPMC5038327 | biostudies-other | 2016 Oct
REPOSITORIES: biostudies-other
Antimicrobial agents and chemotherapy 20160923 10
A rapid decline in the development of new antimicrobial therapeutics has coincided with the emergence of new and more aggressive multidrug-resistant pathogens. Pathogens are protected from antibiotic activity by their ability to enter an aggregative biofilm state. Therefore, disrupting this process in pathogens is a key strategy for the development of next-generation antimicrobials. Here, we present a suite of compounds, based on the Pseudomonas aeruginosa 2-heptyl-4(1H)-quinolone (HHQ) core qui ...[more]