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PD-L1 is a critical mediator of regulatory B cells and T cells in invasive breast cancer.

ABSTRACT: Regulatory T cells (Tregs), a key mediator in regulating anti-tumor immune suppression, tumor immune escape, metastasis and relapse, are considered an important therapeutic target in immunotherapy of human cancers. In the present investigation, elevated CD19(+) CD24(+) CD38(+) regulatory B cells (Bregs) were observed in PBMCs of invasive carcinoma of breast (IBCa) patients compared with that in patients with fibroadenoma (FIBma) or healthy individuals, and the positive correlation existed between Bregs and CD4(+) CD25(+) CD127(-) Tregs (r?=?0.316, P?=?0.001). We found that PD-L1 expression was higher on Bregs in IBCa patients compared with patients with FIBma or healthy individuals (P?

SUBMITTER: Guan H 

PROVIDER: S-EPMC5071845 | biostudies-other | 2016 Oct

REPOSITORIES: biostudies-other

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PD-L1 is a critical mediator of regulatory B cells and T cells in invasive breast cancer.

Guan Honggeng H   Wan Yuqiu Y   Lan Jing J   Wang Qin Q   Wang Zhangyu Z   Li Yecheng Y   Zheng Jiqing J   Zhang Xueguang X   Wang Zemin Z   Shen Yueping Y   Xie Fang F  

Scientific reports 20161020

Regulatory T cells (Tregs), a key mediator in regulating anti-tumor immune suppression, tumor immune escape, metastasis and relapse, are considered an important therapeutic target in immunotherapy of human cancers. In the present investigation, elevated CD19<sup>+</sup> CD24<sup>+</sup> CD38<sup>+</sup> regulatory B cells (Bregs) were observed in PBMCs of invasive carcinoma of breast (IBCa) patients compared with that in patients with fibroadenoma (FIBma) or healthy individuals, and the positive  ...[more]