Ontology highlight
ABSTRACT:
SUBMITTER: Kim SM
PROVIDER: S-EPMC5096903 | biostudies-other | 2016 Nov
REPOSITORIES: biostudies-other
Kim Seong M SM Roy Saurabh G SG Chen Bin B Nguyen Tiffany M TM McMonigle Ryan J RJ McCracken Alison N AN Zhang Yanling Y Kofuji Satoshi S Hou Jue J Selwan Elizabeth E Finicle Brendan T BT Nguyen Tricia T TT Ravi Archna A Ramirez Manuel U MU Wiher Tim T Guenther Garret G GG Kono Mari M Sasaki Atsuo T AT Weisman Lois S LS Potma Eric O EO Tromberg Bruce J BJ Edwards Robert A RA Hanessian Stephen S Edinger Aimee L AL
The Journal of clinical investigation 20160926 11
Oncogenic mutations drive anabolic metabolism, creating a dependency on nutrient influx through transporters, receptors, and macropinocytosis. While sphingolipids suppress tumor growth by downregulating nutrient transporters, macropinocytosis and autophagy still provide cancer cells with fuel. Therapeutics that simultaneously disrupt these parallel nutrient access pathways have potential as powerful starvation agents. Here, we describe a water-soluble, orally bioavailable synthetic sphingolipid, ...[more]