Unknown

Dataset Information

0

Eliminated chromatin of Ascaris contains a gene that encodes a putative ribosomal protein.

ABSTRACT: Chromatin diminution in the nematodes Parascaris equorum and Ascaris lumbricoides leads to the formation of somatic cells that contain less DNA than the germ-line cells. We present molecular evidence for the coding potential of germ-line-specific DNA. We report on a cDNA clone that codes for a putative ribosomal protein (ALEP-1, for A. lumbricoides eliminated protein 1). That the corresponding gene is located in the eliminated portion of the genome indicates a difference in germ-line and somatic ribosomes of A. lumbricoides and P. equorum. Elimination of the ALEP-1 gene from all somatic cells in its fully active state may represent an alternative way to gene regulation.

SUBMITTER: Etter A 

PROVIDER: S-EPMC51070 | biostudies-other | 1991 Mar

REPOSITORIES: biostudies-other

Json Xml
altmetric image

Publications

Eliminated chromatin of Ascaris contains a gene that encodes a putative ribosomal protein.

Etter A A   Aboutanos M M   Tobler H H   Müller F F  

Proceedings of the National Academy of Sciences of the United States of America 19910301 5

Chromatin diminution in the nematodes Parascaris equorum and Ascaris lumbricoides leads to the formation of somatic cells that contain less DNA than the germ-line cells. We present molecular evidence for the coding potential of germ-line-specific DNA. We report on a cDNA clone that codes for a putative ribosomal protein (ALEP-1, for A. lumbricoides eliminated protein 1). That the corresponding gene is located in the eliminated portion of the genome indicates a difference in germ-line and somatic  ...[more]