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Transaminase abnormalities and adaptations of the liver lobule manifest at specific cut-offs of steatosis.

ABSTRACT: There is little documented evidence suggesting that liver fat is responsible for liver injury in the absence of other disease processes. We investigated the relationships between liver fat, aminotransferases and hepatic architecture in liver biopsies with simple steatosis. We identified 136 biopsies with simple steatosis from the Royal Free Hospital Archives with both clinical data and sufficient material. Digital image analysis was employed to measure fat proportionate area (mFPA). Hepatocyte area (HA) and lobule radius (LR) were also measured. There were significant increases in ALT (p?

SUBMITTER: Hall A 

PROVIDER: S-EPMC5247698 | biostudies-other | 2017 Jan

REPOSITORIES: biostudies-other

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Transaminase abnormalities and adaptations of the liver lobule manifest at specific cut-offs of steatosis.

Hall Andrew A   Covelli Claudia C   Manuguerra Roberta R   Luong Tu Vinh TV   Buzzetti Elena E   Tsochatzis Emmanuel E   Pinzani Massimo M   Dhillon Amar Paul AP  

Scientific reports 20170120

There is little documented evidence suggesting that liver fat is responsible for liver injury in the absence of other disease processes. We investigated the relationships between liver fat, aminotransferases and hepatic architecture in liver biopsies with simple steatosis. We identified 136 biopsies with simple steatosis from the Royal Free Hospital Archives with both clinical data and sufficient material. Digital image analysis was employed to measure fat proportionate area (mFPA). Hepatocyte a  ...[more]