Direct Cardiac Cellular Reprogramming for Cardiac Regeneration.

ABSTRACT: Direct cardiac cellular reprogramming of endogenous cardiac fibroblasts directly into induced cardiomyocytes is a highly feasible, promising therapeutic option for patients with advanced heart failure. The most successful cardiac reprogramming strategy will likely be a multimodal approach involving an optimal combination of cardio-differentiating factors, suppression of fibroblast gene expression, and induction of angiogenic factors.

SUBMITTER: Patel V 

PROVIDER: S-EPMC5278776 | biostudies-other | 2016 Sep

REPOSITORIES: biostudies-other