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NFATc1 phosphorylation by DYRK1A increases its protein stability.

ABSTRACT: NFATs are transcription factors involved in immune activation and tumor progression. Previous reports showed that DYRK1A suppressed NFATc2 transcriptional activity through phosphorylation. Nonetheless, our results showed that DYRK1A increased NFATc1/?A protein level and subsequent transcriptional activity. DYRK1A phosphorylation of NFATc1/?A at S261, S278, S403 and S409 interfered with NFATc1 ubiquitination and ubiquitin-proteasome degradation. Our results imply that DYRK1A is a positive kinase in regulation of NFATc1.

SUBMITTER: Liu H 

PROVIDER: S-EPMC5325557 | biostudies-other | 2017

REPOSITORIES: biostudies-other

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NFATc1 phosphorylation by DYRK1A increases its protein stability.

Liu Heng H   Wang Ketao K   Chen Shuai S   Sun Qian Q   Zhang Yuankai Y   Chen Long L   Sun Xiulian X  

PloS one 20170224 2

NFATs are transcription factors involved in immune activation and tumor progression. Previous reports showed that DYRK1A suppressed NFATc2 transcriptional activity through phosphorylation. Nonetheless, our results showed that DYRK1A increased NFATc1/αA protein level and subsequent transcriptional activity. DYRK1A phosphorylation of NFATc1/αA at S261, S278, S403 and S409 interfered with NFATc1 ubiquitination and ubiquitin-proteasome degradation. Our results imply that DYRK1A is a positive kinase  ...[more]

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