Unknown

Dataset Information

0

Pharmacological Blockade of the Chemokine Receptor CCR1 Protects Mice from Systemic Candidiasis of Hematogenous Origin.


ABSTRACT: Systemic candidiasis is a leading cause of nosocomial bloodstream infection with a high mortality rate despite treatment. Immune-based strategies are needed to improve outcomes. We previously reported that genetic deficiency in the chemokine receptor CCR1 improves survival and ameliorates tissue damage in Candida-infected mice. Here, we found that treatment of immunocompetent Candida-infected mice with the CCR1-selective antagonist BL5923 improves survival, decreases the kidney fungal burden, and protects from renal tissue injury.

SUBMITTER: Lionakis MS 

PROVIDER: S-EPMC5328547 | biostudies-other | 2017 Mar

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC6153985 | biostudies-literature
| S-EPMC11914259 | biostudies-literature
| S-EPMC5491531 | biostudies-literature
| S-EPMC3372818 | biostudies-literature
| S-EPMC3328601 | biostudies-literature
2012-01-01 | E-GEOD-34492 | biostudies-arrayexpress
| S-EPMC10513123 | biostudies-literature
| S-EPMC3420964 | biostudies-literature
| S-EPMC2583981 | biostudies-literature
2025-02-20 | GSE282799 | GEO