Effects of hyaluronic acid on bleeding following third molar extraction.

ABSTRACT: To explore the effects of hyaluronic acid (HA) on bleeding and associated outcomes after third molar extraction.Forty patients who had undergone molar extraction were randomly divided into two groups; 0.8% (w/v) HA was applied to the HA group (n=20) whereas a control group (n=20) was not treated. Salivary and gingival tissue factor (TF) levels, bleeding time, maximum interincisal opening (MIO), pain scored on a visual analog scale (VAS), and the swelling extent were compared between the two groups.HA did not significantly affect gingival TF levels. Salivary TF levels increased significantly 1 week after HA application but not in the control group. Neither the VAS pain level nor MIO differed significantly between the two groups. The swelling extent on day 3 and the bleeding time were greater in the HA group than in the control group.Local injection of HA at 0.8% prolonged the bleeding time, and increased hemorrhage and swelling in the early postoperative period after third molar extractions.

SUBMITTER: Gocmen G 

PROVIDER: S-EPMC5393542 | biostudies-other | 2017 Mar-Apr

REPOSITORIES: biostudies-other