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Directing cell migration with asymmetric micropatterns.

ABSTRACT: This report shows that the direction of polarization of attached mammalian cells determines the direction in which they move. Surfaces micropatterned with appropriately functionalized self-assembled monolayers constrain individual cells to asymmetric geometries (for example, a teardrop); these geometries polarize the morphology of the cell. After electrochemical desorption of the self-assembled monolayers removes these constraints and allows the cells to move across the surface, they move toward their blunt ends.

SUBMITTER: Jiang X 

PROVIDER: S-EPMC545855 | biostudies-other | 2005 Jan

REPOSITORIES: biostudies-other

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Directing cell migration with asymmetric micropatterns.

Jiang Xingyu X   Bruzewicz Derek A DA   Wong Amy P AP   Piel Matthieu M   Whitesides George M GM  

Proceedings of the National Academy of Sciences of the United States of America 20050114 4

This report shows that the direction of polarization of attached mammalian cells determines the direction in which they move. Surfaces micropatterned with appropriately functionalized self-assembled monolayers constrain individual cells to asymmetric geometries (for example, a teardrop); these geometries polarize the morphology of the cell. After electrochemical desorption of the self-assembled monolayers removes these constraints and allows the cells to move across the surface, they move toward  ...[more]