Ontology highlight
ABSTRACT:
SUBMITTER: Horn AV
PROVIDER: S-EPMC5478143 | biostudies-other | 2017 Jun
REPOSITORIES: biostudies-other
PLoS genetics 20170606 6
Long interspersed nuclear element-1s (LINE-1s, or L1s) are an active family of retrotransposable elements that continue to mutate mammalian genomes. Despite the large contribution of L1 to mammalian genome evolution, we do not know where active L1 particles (particles in the process of retrotransposition) are located in the cell, or how they move towards the nucleus, the site of L1 reverse transcription. Using a yeast model of LINE retrotransposition, we identified ESCRT (endosomal sorting compl ...[more]