Ontology highlight
ABSTRACT:
SUBMITTER: Xia C
PROVIDER: S-EPMC5493669 | biostudies-other | 2017 Jun
REPOSITORIES: biostudies-other
Xia Caixia C Shui Liyan L Lou Guohua G Ye Bingjue B Zhu Wei W Wang Jing J Wu Shanshan S Xu Xiao X Mao Long L Xu Wanhong W Chen Zhi Z Liu Yanning Y Zheng Min M
Scientific reports 20170630 1
DNA-damaging agents have been used in cancer chemotherapy for a long history. Unfortunately, chemotherapeutic treatment strategies against hepatocellular carcinoma (HCC) are still ineffective. We screened a novel DNA-damaging compound, designated as 0404, by using time-dependent cellular response profiling (TCRP) based on unique DNA-damage characteristics. We used human HCC cell lines and HCC xenograft mouse model to analyze the anti-cancer effects of 0404. Transcriptome and miRNA arrays were us ...[more]