Epigenetics and neural stem cell commitment.

ABSTRACT: Neural stem cell is presently the research hotspot in neuroscience. Recent progress indicates that epigenetic modulation is closely related to the self-renewal and differentiation of neural stem cell. Epigenetics refer to the study of mitotical/meiotical heritage changes in gene function that cannot be explained by changes in the DNA sequence. Major epigenetic mechanisms include DNA methylation, histone modification, chromatin remodeling, genomic imprinting, and non-coding RNA. In this review, we focus on the new insights into the epigenetic mechanism for neural stem cells fate.

SUBMITTER: Tang HL 

PROVIDER: S-EPMC5550588 | biostudies-other | 2007 Jul

REPOSITORIES: biostudies-other