CPEB4 links the clock and the UPR to protect the liver.

ABSTRACT: Under misfolded protein stress, the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) to restore homeostasis, or commits the cell to apoptosis. A study now uncovers how the UPR is governed by the circadian clock to adjust ER protein-folding capacity to metabolic demand and protect against liver damage.

SUBMITTER: Moore PC 

PROVIDER: S-EPMC5555618 | biostudies-other | 2017 Jan

REPOSITORIES: biostudies-other