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Bulky Pelvic Hodgkin Lymphoma in a Prepubertal Girl.

ABSTRACT: Pure infra-diaphragmatic presentation is rare in pediatric Hodgkin lymphoma (HL). Isolated pelvic presentation is restricted to case reports in adults. We describe a unique presentation of HL as a primary pelvic disease in an 11-year-old prepubertal girl. She was treated based on the Euronet-Paediatric Hodgkin's Lymphoma Group protocol (EuroNet-PHL-C1) recommendations and assigned to treatment Group 2 (Stage IIB). The patient had bulky disease and a suboptimal response on interim 18-fluorodeoxyglucose positron emission tomography. The child was administered chemotherapy alone. Pelvic radiotherapy was consciously avoided due to the high risk of gonadal failure. She remains disease-free for 18 months now. Treatment of pediatric HL necessitates a delicate balance between achieving cure as well as avoiding serious late effects of therapy.

SUBMITTER: Totadri S 

PROVIDER: S-EPMC5582567 | biostudies-other | 2017 Apr-Jun

REPOSITORIES: biostudies-other

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Bulky Pelvic Hodgkin Lymphoma in a Prepubertal Girl.

Totadri Sidharth S   Bansal Deepak D   Bal Amanjit A   Menon Prema P  

Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology 20170401 2

Pure infra-diaphragmatic presentation is rare in pediatric Hodgkin lymphoma (HL). Isolated pelvic presentation is restricted to case reports in adults. We describe a unique presentation of HL as a primary pelvic disease in an 11-year-old prepubertal girl. She was treated based on the Euronet-Paediatric Hodgkin's Lymphoma Group protocol (EuroNet-PHL-C1) recommendations and assigned to treatment Group 2 (Stage IIB). The patient had bulky disease and a suboptimal response on interim 18-fluorodeoxyg  ...[more]