Ontology highlight
ABSTRACT:
SUBMITTER: Schwartz C
PROVIDER: S-EPMC5584124 | biostudies-other | 2017 Sep
REPOSITORIES: biostudies-other
The Journal of experimental medicine 20170726 9
Group 2 innate lymphoid cells (ILC2s) are important effector cells driving the initiation of type 2 immune responses leading to adaptive T helper 2 (Th2) immunity. Here we show that ILC2s dynamically express the checkpoint inhibitor molecule PD-L1 during type 2 pulmonary responses. Surprisingly, PD-L1:PD-1 interaction between ILC2s and CD4<sup>+</sup> T cells did not inhibit the T cell response, but PD-L1-expressing ILC2s stimulated increased expression of GATA3 and production of IL-13 by Th2 ce ...[more]