Ontology highlight
ABSTRACT:
SUBMITTER: Walseng E
PROVIDER: S-EPMC5587706 | biostudies-other | 2017 Sep
REPOSITORIES: biostudies-other
Walseng Even E Köksal Hakan H Sektioglu Ibrahim M IM Fåne Anne A Skorstad Gjertrud G Kvalheim Gunnar G Gaudernack Gustav G Inderberg Else Marit EM Wälchli Sébastien S
Scientific reports 20170906 1
Effector T cells equipped with engineered antigen receptors specific for cancer targets have proven to be very efficient. Two methods have emerged: the Chimeric Antigen Receptors (CARs) and T-cell Receptor (TCR) redirection. Although very potent, CAR recognition is limited to membrane antigens which represent around 1% of the total proteins expressed, whereas TCRs have the advantage of targeting any peptide resulting from cellular protein degradation. However, TCRs depend on heavy signalling mac ...[more]