Ontology highlight
ABSTRACT:
SUBMITTER: Li YE
PROVIDER: S-EPMC5591525 | biostudies-other | 2017 Sep
REPOSITORIES: biostudies-other
Genome biology 20170908 1
Crosslinking immunoprecipitation sequencing (CLIP-seq) technologies have enabled researchers to characterize transcriptome-wide binding sites of RNA-binding protein (RBP) with high resolution. We apply a soft-clustering method, RBPgroup, to various CLIP-seq datasets to group together RBPs that specifically bind the same RNA sites. Such combinatorial clustering of RBPs helps interpret CLIP-seq data and suggests functional RNA regulatory elements. Furthermore, we validate two RBP-RBP interactions ...[more]