Ontology highlight
ABSTRACT:
SUBMITTER: Kopinja J
PROVIDER: S-EPMC5653818 | biostudies-other | 2017 Oct
REPOSITORIES: biostudies-other
Scientific reports 20171023 1
Mutations in IDH1 are highly prevalent in human glioma. First line treatment is radiotherapy, which many patients often forego to avoid treatment-associated morbidities. The high prevalence of IDH1 mutations in glioma highlights the need for brain-penetrant IDH1 mutant-selective inhibitors as an alternative therapeutic option. Here, we have explored the utility of such an inhibitor in IDH1 mutant patient-derived models to assess the potential therapeutic benefits associated with intracranial 2-H ...[more]