Ontology highlight
ABSTRACT:
SUBMITTER: Jakel C
PROVIDER: S-EPMC5673892 | biostudies-other | 2017 Nov
REPOSITORIES: biostudies-other
Nature communications 20171106 1
Pancreatic acinar cell carcinoma (ACC) is an aggressive exocrine tumor with largely unknown biology. Here, to identify potential targets for personalized treatment, we perform integrative genome-wide and epigenome-wide analyses. The results show frequently aberrant DNA methylation, abundant chromosomal amplifications and deletions, and mutational signatures suggesting defective DNA repair. In contrast to pancreatic ductal adenocarcinoma, no recurrent point mutations are detected. The tumor suppr ...[more]