Ontology highlight
ABSTRACT:
SUBMITTER: Kim HS
PROVIDER: S-EPMC5688089 | biostudies-other | 2017 Nov
REPOSITORIES: biostudies-other
Nature communications 20171115 1
Receptor activator of NF-kB ligand (RANKL) generates intracellular reactive oxygen species (ROS), which increase RANKL-mediated signaling in osteoclast (OC) precursor bone marrow macrophages (BMMs). Here we show that a ROS scavenging protein DJ-1 negatively regulates RANKL-driven OC differentiation, also called osteoclastogenesis. DJ-1 ablation in mice leads to a decreased bone volume and an increase in OC numbers. In vitro, the activation of RANK-dependent signals is enhanced in DJ-1-deficient ...[more]