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Postaxial limb hypoplasia (PALH): the classification, clinical features, and related developmental biology.


ABSTRACT: Postaxial limb hypoplasia (PALH) is a group of nonhereditary diseases with congenital lower limb deficiency affecting the fibular ray, including fibular hemimelia, proximal femoral focal deficiency, and tarsal coalition. The etiology and the developmental biology of the anomaly are still not fully understood. Here, we review the previous classification systems, present the clinical features, and discuss the developmental biology of PALH.

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC5730483 | biostudies-other | 2017 Dec

REPOSITORIES: biostudies-other

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Postaxial limb hypoplasia (PALH): the classification, clinical features, and related developmental biology.

Zhang Zeng Z   Yi Dan D   Xie Rong R   Hamilton John L JL   Kang Qing-Lin QL   Chen Di D  

Annals of the New York Academy of Sciences 20171009 1


Postaxial limb hypoplasia (PALH) is a group of nonhereditary diseases with congenital lower limb deficiency affecting the fibular ray, including fibular hemimelia, proximal femoral focal deficiency, and tarsal coalition. The etiology and the developmental biology of the anomaly are still not fully understood. Here, we review the previous classification systems, present the clinical features, and discuss the developmental biology of PALH. ...[more]

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