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Spatiotemporal Control of Acetyl-CoA Metabolism in Chromatin Regulation.


ABSTRACT: The epigenome is sensitive to the availability of metabolites that serve as substrates of chromatin-modifying enzymes. Links between acetyl-CoA metabolism, histone acetylation, and gene regulation have been documented, although how specificity in gene regulation is achieved by a metabolite has been challenging to answer. Recent studies suggest that acetyl-CoA metabolism is tightly regulated both spatially and temporally to elicit responses to nutrient availability and signaling cues. Here we discuss evidence that acetyl-CoA production is differentially regulated in the nucleus and cytosol of mammalian cells. Recent findings indicate that acetyl-CoA availability for site-specific histone acetylation is influenced through post-translational modification of acetyl-CoA-producing enzymes, as well as through dynamic regulation of the nuclear localization and chromatin recruitment of these enzymes.

SUBMITTER: Sivanand S 

PROVIDER: S-EPMC5741483 | biostudies-other | 2018 Jan

REPOSITORIES: biostudies-other

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Spatiotemporal Control of Acetyl-CoA Metabolism in Chromatin Regulation.

Sivanand Sharanya S   Viney Isabella I   Wellen Kathryn E KE  

Trends in biochemical sciences 20171123 1


The epigenome is sensitive to the availability of metabolites that serve as substrates of chromatin-modifying enzymes. Links between acetyl-CoA metabolism, histone acetylation, and gene regulation have been documented, although how specificity in gene regulation is achieved by a metabolite has been challenging to answer. Recent studies suggest that acetyl-CoA metabolism is tightly regulated both spatially and temporally to elicit responses to nutrient availability and signaling cues. Here we dis  ...[more]

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2022-09-25 | GSE137977 | GEO