Dataset Information
Three New Cytotoxic Steroidal Glycosides Isolated from Conus pulicarius Collected in Kosrae, Micronesia.
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ABSTRACT:
SUBMITTER: Lee YJ
PROVIDER: S-EPMC5742839 | biostudies-other | 2017 Dec
REPOSITORIES: biostudies-other
Publications
Three New Cytotoxic Steroidal Glycosides Isolated from Conus pulicarius Collected in Kosrae, Micronesia.
Marine drugs 20171204 12
Three new sulfated steroidal glycosides (<b>3</b>-<b>5</b>), along with known cholesterol derivatives (<b>1</b>,<b>2</b>), were isolated from the visceral extract of the cone snail <i>Conus pulicarius</i>. The structure of each new compound was elucidated by nuclear magnetic resonance spectroscopy and high-resolution mass spectrometry. The three new compounds exhibited significant in vitro cytotoxicity (GI<sub>50</sub> values down to 0.49 μM) against the K562 human leukemia cell line. ...[more]