Ontology highlight
ABSTRACT:
SUBMITTER: Reidling JC
PROVIDER: S-EPMC5768890 | biostudies-other | 2018 Jan
REPOSITORIES: biostudies-other
Stem cell reports 20171207 1
Huntington's disease (HD) is an inherited neurodegenerative disorder with no disease-modifying treatment. Expansion of the glutamine-encoding repeat in the Huntingtin (HTT) gene causes broad effects that are a challenge for single treatment strategies. Strategies based on human stem cells offer a promising option. We evaluated efficacy of transplanting a good manufacturing practice (GMP)-grade human embryonic stem cell-derived neural stem cell (hNSC) line into striatum of HD modeled mice. In HD ...[more]