Ontology highlight
ABSTRACT:
SUBMITTER: Dagogo-Jack I
PROVIDER: S-EPMC5785105 | biostudies-other | 2018
REPOSITORIES: biostudies-other
Dagogo-Jack Ibiayi I Brannon A Rose AR Ferris Lorin A LA Campbell Catarina D CD Lin Jessica J JJ Schultz Katherine R KR Ackil Jennifer J Stevens Sara S Dardaei Leila L Yoda Satoshi S Hubbeling Harper H Digumarthy Subba R SR Riester Markus M Hata Aaron N AN Sequist Lecia V LV Lennes Inga T IT Iafrate A John AJ Heist Rebecca S RS Azzoli Christopher G CG Farago Anna F AF Engelman Jeffrey A JA Lennerz Jochen K JK Benes Cyril H CH Leary Rebecca J RJ Shaw Alice T AT Gainor Justin F JF
JCO precision oncology 20180123
<h4>Purpose</h4><i>ALK</i> rearrangements predict for sensitivity to ALK tyrosine kinase inhibitors (TKIs). However, responses to ALK TKIs are generally short-lived. Serial molecular analysis is an informative strategy for identifying genetic mediators of resistance. Although multiple studies support the clinical benefits of repeat tissue sampling, the clinical utility of longitudinal circulating tumor DNA analysis has not been established in ALK-positive lung cancer.<h4>Methods</h4>Using a 566- ...[more]