Ontology highlight
ABSTRACT:
SUBMITTER: Stirling F
PROVIDER: S-EPMC5812007 | biostudies-other | 2017 Nov
REPOSITORIES: biostudies-other
Molecular cell 20171101 4
The evolutionary stability of synthetic genetic circuits is key to both the understanding and application of genetic control elements. One useful but challenging situation is a switch between life and death depending on environment. Here are presented "essentializer" and "cryodeath" circuits, which act as kill switches in Escherichia coli. The essentializer element induces cell death upon the loss of a bi-stable cI/Cro memory switch. Cryodeath makes use of a cold-inducible promoter to express a ...[more]