Ontology highlight
ABSTRACT:
SUBMITTER: Shan Y
PROVIDER: S-EPMC5841433 | biostudies-other | 2018 Mar
REPOSITORIES: biostudies-other
Cell death & disease 20180307 3
Exosomes are nano-vesicles secreted by tumor cells. Exosomes can transfer complex biological information and induce a diverse signaling response in a wide array of pathological conditions, such as hypoxia. Hypoxia is associated with aggressive phenotypes and poor outcomes in nasopharyngeal carcinoma (NPC) patients. Here, we analyzed the role of exosomes from hypoxic NPC cells in enhancing the metastases of normoxic cells in a hypoxia-induced factor-1α (HIF-1α)-dependent manner. HIF-1α rapidly ac ...[more]