Consequences of Rab GTPase dysfunction in genetic or acquired human diseases.
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ABSTRACT:
SUBMITTER: Banworth MJ
PROVIDER: S-EPMC5902184 | biostudies-other | 2018 Mar
REPOSITORIES: biostudies-other
Publications
Consequences of Rab GTPase dysfunction in genetic or acquired human diseases.
Banworth Marcellus J MJ Li Guangpu G
Small GTPases 20171228 1-2
Rab GTPases are important regulators of intracellular membrane trafficking in eukaryotes. Both activating and inactivating mutations in Rab genes have been identified and implicated in human diseases ranging from neurological disorders to cancer. In addition, altered Rab expression is often associated with disease prognosis. As such, the study of diseases associated with Rabs or Rab-interacting proteins has shed light on the important role of intracellular membrane trafficking in disease etiolog ...[more]
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