Ontology highlight
ABSTRACT:
SUBMITTER: Yu SH
PROVIDER: S-EPMC5972518 | biostudies-other | 2018 Feb
REPOSITORIES: biostudies-other
Biochimica et biophysica acta. Gene regulatory mechanisms 20180131 2
The histone demethylase Jmjd3 plays a critical role in cell lineage specification and differentiation at various stages of development. However, its function during normal myeloid development remains poorly understood. Here, we carried out a systematic in vivo screen of epigenetic factors for their function in hematopoiesis and identified Jmjd3 as a new epigenetic factor that regulates myelopoiesis in zebrafish. We demonstrated that jmjd3 was essential for zebrafish primitive and definitive myel ...[more]