Unknown

Dataset Information

0

Rhodium-catalyzed asymmetric hydroamination and hydroindolation of keto-vinylidenecyclopropanes.

ABSTRACT: We reported a highly regio- and enantioselective hydroamination and hydroindolation of keto-vinylidenecyclopropanes via cationic Rh(i) catalysis in this context. The combination of various secondary amines and indoles with keto-vinylidenecyclopropanes afforded the corresponding hydrofunctionalization products in good to excellent yields with outstanding ee values under mild conditions. A new TMM-Rh model complex was proposed, providing an atom economical Rh-?-allyl precursor at the same time. Moreover, the resulting products could easily be transformed into more complex polyheterocycles upon further synthetic manipulation.

SUBMITTER: Yang S 

PROVIDER: S-EPMC5994874 | biostudies-other | 2018 Jun

REPOSITORIES: biostudies-other

Json Xml
altmetric image

Publications

Rhodium-catalyzed asymmetric hydroamination and hydroindolation of keto-vinylidenecyclopropanes.

Yang Song S   Li Quan-Zhe QZ   Xu Chen C   Xu Qin Q   Shi Min M  

Chemical science 20180511 22

We reported a highly regio- and enantioselective hydroamination and hydroindolation of keto-vinylidenecyclopropanes <i>via</i> cationic Rh(i) catalysis in this context. The combination of various secondary amines and indoles with keto-vinylidenecyclopropanes afforded the corresponding hydrofunctionalization products in good to excellent yields with outstanding ee values under mild conditions. A new TMM-Rh model complex was proposed, providing an atom economical Rh-π-allyl precursor at the same t  ...[more]