Ontology highlight
ABSTRACT:
SUBMITTER: Lei AH
PROVIDER: S-EPMC6080904 | biostudies-other | 2018 Aug
REPOSITORIES: biostudies-other
The Journal of experimental medicine 20180726 8
Group 2 innate lymphoid cells (ILC2s) are emerging as key players in the pathogenesis of allergic airway inflammation. The mechanisms regulating ILC2, however, are not fully understood. Here, we found that ICAM-1 is required for the development and function of ILC2. ICAM-1-deficient (<i>ICAM-1<sup>-/-</sup></i> ) mice displayed significantly lower levels of ILC2s in the bone marrow and peripheral tissues than wild-type controls. CLP transfer and in vitro culture assays revealed that the regulati ...[more]