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Translational applications of microRNAs in cancer, and therapeutic implications.

ABSTRACT: The search for targeted novel therapies for cancer is ongoing. MicroRNAs (miRNAs) display a number of characteristics making them an attractive and realisable option. In this review, we explore these applications, ranging from diagnostics, prognostics, disease surveillance, to being a primary therapy or a tool to sensitise patients to treatment modalities such as chemotherapy and radiotherapy. We take a particular perspective towards miRNAs and their impact on rare cancers. Advancement in the delivery of miRNAs, from viral vectors and liposomal delivery to nanoparticle based, has led to a number of pre-clinical and clinical applications for microRNA cancer therapeutics. This is promising, especially in the setting of rare cancers.

SUBMITTER: Kwok GT 

PROVIDER: S-EPMC6084838 | biostudies-other | 2017 Sep

REPOSITORIES: biostudies-other

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Translational applications of microRNAs in cancer, and therapeutic implications.

Kwok Grace T GT   Zhao Jing Ting JT   Weiss Jocelyn J   Mugridge Nancy N   Brahmbhatt Himanshu H   MacDiarmid Jennifer A JA   Robinson Bruce G BG   Sidhu Stan B SB  

Non-coding RNA research 20170901 3-4

The search for targeted novel therapies for cancer is ongoing. MicroRNAs (miRNAs) display a number of characteristics making them an attractive and realisable option. In this review, we explore these applications, ranging from diagnostics, prognostics, disease surveillance, to being a primary therapy or a tool to sensitise patients to treatment modalities such as chemotherapy and radiotherapy. We take a particular perspective towards miRNAs and their impact on rare cancers. Advancement in the de  ...[more]