Ontology highlight
ABSTRACT:
SUBMITTER: Quinones N
PROVIDER: S-EPMC6099682 | biostudies-other | 2018 Jun
REPOSITORIES: biostudies-other
Molecules (Basel, Switzerland) 20180612 6
We describe the syntheses of nine new angucyclinone 6-aza-analogues, achieved through a hetero Diels-Alder reaction between the shikimic acid derivative-azadiene <b>13</b>, with different naphthoquinones. The cytotoxic activity of the new synthesized compounds and five angucyclinones, previously reported, was evaluated in vitro against three cancer cell lines: PC-3 (prostate cancer), HT-29 (colon cancer), MCF-7 (breast cancer), and one non-tumoral cell line, human colon epithelial cells (CCD841 ...[more]